Take route 41 North toward Bradenton. Turn left on 53rd and continue on 53rd until it curves to the right and becomes 75th Street. Stay on 75th until you reach Manatee Ave. (Route 64). Turn left onto Manatee Avenue and continue until it ends at Gulf Drive. Turn right onto Gulf Drive and follow it until you reach Island Garden Villas on the right. (approx. 30 minute drive)
Take I-275 South toward St. Petersburg. After Skyway Bridge, follow signs to Route 19 South. Follow Route 19 South to Business 41 South through Palmetto until you come to Route 64 West (Manatee Avenue), and turn right to Anna Maria Island. Turn right on Gulf Drive. Follow Gulf Drive until you see Island Garden Villas on the right. (approx. a 1 hour drive)
Follow signs for I-4 West toward Tampa. Take I-75 South to Route 64 (Exit 220, Manatee Avenue) West to Anna Maria Island. Turn right on Gulf Drive. Follow Gulf Drive until you see Island Garden Villas on your right. (approx. a 2.5 hour drive)